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**The History Palette** The History palette (Figure 7-3) is located to the right of the Layers palette. By default, the History palette shows you the last 20 image adjustments you made. It also shows whether or not an image is a _luminance mask_. A _luminance mask_ is an image that can be printed at a higher image size than the image itself because the color values of the mask are compressed in the file. When you see this symbol, you have a choice: either deselect (remove) it, or go to the Layers palette, click the Symbol box, and then choose _None_ for the luminance mask option. **Figure 7-3** The History palette is on the right side of your image.



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Adobe Photoshop Lightroom is a professional RAW editor, RAW converter and asset management software for photographers. Adobe InDesign is a design tool to create interactive websites, magazines and brochures. Adobe Illustrator is a drawing and vector graphics tool used to create logos, illustrations, charts, photo manipulations and more. The following list of online resources is a combination of a list of where to go to learn about the software and other useful sources of information and a list of websites that you can use as a resource when learning to use Photoshop, Lightroom, InDesign, Illustrator or Photoshop Elements for free. Each website that is linked below comes with its own material in the form of text, videos, pictures, documents, courses and other educational resources. When possible, we have also included a link back to the source so that you can access the material that is available on that site as a resource. Make sure that you read all information available on a website before downloading any material or using it in any way. Yes, I agree that Adobe should be helping to fund the creation of content on this page. The official Adobe website The official Adobe website provides a wealth of information about Photoshop, Lightroom, InDesign and Illustrator. It even has a link to a large library of PDF educational books and other educational material. Adobe Photoshop The official Adobe Photoshop website features tutorials, books, reference guides and more. Adobe Photoshop Lightroom The official Adobe Photoshop Lightroom website has everything you could ever want to know about the software. Adobe InDesign The official Adobe InDesign website has everything you could ever want to know about the software. Adobe Illustrator The official Adobe Illustrator website has everything you could ever want to know about the software. Adobe Photoshop Stack Exchange Stack Exchange is the Q&A site for users of all Adobe products. Learn by watching tutorials created by Adobe education employees. Explore websites and communities run by Adobe Photoshop enthusiasts. Adobe Photoshop User Gallery The Adobe Photoshop User Gallery is filled with creative resources for photographers, graphic designers, web designers, Discord emoji creators and meme-makers. The Adobe Photoshop User Gallery is in no way affiliated with the official Adobe Photoshop Support Forum or Adobe Photoshop General Forum. Adobe PhotoShop tutorials The Adobe PhotoShop tutorials are run by Adobe employees that have a wealth of knowledge about how to use Photoshop 05a79cecff



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Loss of hepatic glycogen in patients with non-alcoholic fatty liver. To investigate the pathogenesis of non-alcoholic fatty liver in humans, the glycogen content and structure of liver tissue obtained from patients was studied. The glycogen content in the liver was decreased and its size was increased in patients with non-alcoholic fatty liver (NAFL) compared with those in normal controls. A loss of glycogen was consistently observed even in patients with histologically proven simple steatosis, even in the absence of the symptoms of type 2 diabetes mellitus or hyperlipidemia. The loss of hepatic glycogen in NAFL patients was associated with increasing serum transaminase activity, increasing hepatic triglyceride content, and decreasing HDL cholesterol levels. The decrease in glycogen content in the liver of NAFL patients correlated closely with the increase in fasting blood glucose level. These results indicate that a loss of hepatic glycogen is associated with glucose intolerance in patients with NAFL.![](transmedchirsocedinb81290-0172){#sp1.146} ![](transmedchirsocedinb81290-0173){#sp2.147} ![](transmedchirsocedinb81290-0174){#sp3.148} ![](transmedchirsocedinb81290-0175){#sp4.149} ![](transmedchirsocedinb81290-0176){#sp5.150} ![](transmedchirsocedinb81290-0177){#sp6.151} ![](transmedchirsocedinb81290-0178){#sp7.152} ![](transmedchirsocedinb81290-0179){#sp8.153} ![](transmedchirsocedinb81290-0180){#sp9.154} ![](transmedchirsocedinb81290-0181){#sp10.155} ![](transmedchirsocedinb81290-0182){#sp11.156} ![](transmedchirsocedinb81290-0183){#sp12.157} ![](transmedchirsocedin



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The molecule centric approach to the design of inhibitors of the 20S proteasome via systematic modification of the catalytic site with a series of proteasome active site-targeted dipeptidyl carboxypeptidase-like (DPL) inhibitors. We describe the application of a "molecule centric" strategy to the design and synthesis of a series of potent, cell-active, and stable dipeptidyl carboxypeptidase-like (DPL) inhibitors, which were targeted towards the proteasome. The drug-like molecules investigated contain a P1/P2 linked, N-terminal keto amine containing dipeptide sequence which occupies the wide open S5-S6 peptide binding pockets of the 20S proteasome. Synthesis of these molecules was conducted using an iterative approach whereby the peptide N-terminus was systematically replaced by various bioisosteric moieties in an effort to decrease chemical complexity, provide a redox tunable spacer, and improve oral bioavailability. The most potent member of this series, L-234,802 exhibits biochemical activity in the low micromolar range (Ki = 6.2nM) and against the B16F10 melanoma cell line is oral bioavailable (P.O. ED50 = 3.0 mg/kg). This is the first synthetic compound to provide a structurally defined lead which is both drug-like and able to penetrate the central nervous system when administered systemically.Photo: Makena Kelly. Graphic: Gersh/Getty Images. The worst in-flight air-conditioning systems in the world tend to be found in economy class—not even first class. That’s according to a new survey of international passenger surveys released today by AirHelp, a customer-service company that works closely with Air Canada. And it’s true that the small differences in comfort between premium and economy class on the airline network are really just that: a small difference. But it may be the difference between sweating profusely on a seven-hour flight versus a one-hour flight. The survey, which was commissioned by AirHelp and rated each airline using ten criteria, found that two in ten (20 per cent) of economy-class passengers were either “very dissatisfied” or “somewhat dissatisfied” with their air-conditioning. The



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